Diplom Biologist; Priv.-Doz. Dr.
I am a biologist and started my scientific career with engineering of cell-permeable proteins. Tissue-engineering appeared as a fascinating new field of research to me and I was wondering if there will be fully artificial organs and even designer tissues with exciting new feature some day in the future (just think of the third generation Terminator). For this reason I joined Jürgen Heschelers laboratory to work on stem cells and tissue engineering.
If I am not in the lab you find me in the garden, motorbiking or on a ride with the horses.
Anne is a veterinarian with experience in equine practice and performs experiments in the scope of a DVM study co-supervised by Prof. Burk (Tiermedizinische Hochschule Giessen). Anne is focussing on aspects of equine stem cell technologies to identify novel treatments of equine orthopaedic diseases. This type of research brings stem cell technology to the clinics and paves the way for applications in humans as well.
Aseel is a PhD student from Iraq. She is focussing on the interaction of human iPS cell derived cardiomyocytes and murine primary cardiomyocytes with polyacrylamide hydrogel matrices of defined elasticity to gain knowledge on the interplay between matrix stiffness and cardiomyocyte physiology. Aseels experiments are important to better understand the role of cardiomyocytes in cardiac fibrosis and predict the interaction of transplanted cardiomyocytes into infarction scar tissue.
Technical assistant: Human Stem Cell Culture and Differentiation
Daniel is managing the cell culture laboratory for our group. He is performing all experiments with transgenic cell lines in the frame of the collboration with GoBio GmbH. In addition Daniel holds great expertise in murine and human pluripotent stem cell culture and cardiac differentiation. Together with Sarkawt he is managing the culture and differentiation of the human stem cells and the development of protocols and methods for scalable production of these cells for preclinical approaches. In his free time Daniel is a master in martial arts.
Technical assistant: Cell Culture Technologies
Ellen is specialist on murine stem cell culture and differentiation. She is performing murine cardiomyocytes differentiation and culture for the group and supports our intensive collaboration with the cardiothoracical surgery department. Furthermore, Ellen has broad skills in the laboratory including molecular biology and preparation of cell culture hydrogel substrates from polyacrylamide.
Postdoctoral Researcher: Electrophysiology of cardiac cell therapy
Gabriel Peinkofer is interested in the course of cardiomyocyte engraftment after transplantation into infarcted hearts. The integration of the cells is analysed by a method called "sharp electrodes". Gabriel transplants green fluorescent cells and analyses the electrical engraftment of the cells by impaling them with sharp glas electrodes to quantify the quality of electrical coupling and the degree of maturation. Specific skills include cell culture, cell transplantation in a murine model of cardiac infarction and electrophysiology.
(Project in collaboration with Priv.-Doz. Dr. Marcel Halbach, Heart Center Cologne)
Karim has a background of human genetics and biomedical sciences from Iran. He joints the lab to apply cellular and molecular cutting edge approaches aiming to push forward cardiovascular research specifically in the area of cardiac failure and fibrosis.
Karina supports the team as scientific assistant. She is mainly focussed on supporting our team with the human stem cell culture and performs a collaborative project on improving the purity of stem cell derived cardiomyocytes for preclinical applications.
Philipp is performing his medical doctor thesis in the laboratory. He is interested to optimize a microfluidics-based workflow to generate micro-tissues for 3D cell culture and as a starting material for transplantation purposes.
DVM, Dr. rer. medic.
I am a veterinarian born in 1980 Sindh Pakistan, the focus of my research area is cardiac cell replacement therapy and tissue engineering; particularly murine models for cardiac regeneration. My research interest is to develop novel therapeutic approaches such as micro-tissue engineering or use of degradable biomaterials for in vivo improvement of early cell retention.
BSc. Biology; MSc. Physiology; PhD
Sarkawt is a PhD student in “Interdisciplinary Program Health Sciences - Medical Faculty”. He is focusing on two main projects in his PhD study: Firstly, he is looking for a new non-invasive technique for tracking cells after transplanting into organ tissues. Secondly, he is working on the scalable generating of human induced pluripotent stem cell-derived cardiomyocytes (HiPSC-CM). Beside PhD projects Sarkawt with his colleagues is interested in cardiac tissue engineering. We postulate that engineering cardiac tissue for future transplantation is a promise technique to fully recovery the infarct area after myocardial infarction.
MSc. Education in Biology and Geography
Lisa Münchhalfen is a PhD student at the Medical Faculty. In her project she is focussing on the process of organ complementation in the mouse in order to define a strategy to ultimately replace the cardiac lineage with derivatives of foreign stem cells in a interspecies chimaera.
MSc. in Chemistry
Stephanie is a chemist and works on novel technologies of hydrogel-based cell culturing strategies. She is performing her PhD thesis in a collaboration between the Institute of Physical Chemistry, Cologne and the Center for Physiology bringing together expertise from different fields of natural sciences.
Anna Lena Weiß, Dr. rer. medic.
Denise Roggan, BSc.
Farooq Mohammad, PhD
Jenni Lam, Dr. rer. medic.
Lukas Linden, BSc.
Nelly Mikhael, PhD
Shahab Khalaf, MSc.
Uta Chrzanowski, BSc.
Xiaowu Sheng, Dr., Current affiliation: Xiangya School of Medicine, Changsa, China
Yasmin Mokhtar, Msc,